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What is “Robotic Pill” and How Does it Deliver mRNA Through the Stomach Lining?


Two weeks ago, Dr. Peter McCullough, a controversial doctor who speaks out against COVID-19 vaccines and the broken healthcare system in general, published an article warning the health professionals and the public about the so-called “robotic pill” which would deliver mRNA into the stomach lining. Dr. McCullough started to express his concern against mRNA technology in medicine upon discovering hundreds of reports regarding the side effects of mRNA COVID-19 vaccine which include cardiac arrest, strokes, nerve damage, blood clots, and even deaths. Pertaining to this new technology that is now being carried out in clinical studies, Dr. McCullough commented:     


“I can tell you as a doctor, I would be very concerned this could lead to even bigger complications than an injection in the arm.”

What is Robotic Pill and how does it work

The study for “robotic pill” was initiated in March of last year by a team led by Prof. Giovanni Traverso, a Koch Institute research affiliate, and Robert Langer, also a professor from Massachusetts Institute of Technology (MIT). The two professors are known “pioneers and leaders in the field of drug delivery and biomedical devices”. They came up with the design for the “robotic pill” and conceptualized the use of this technology for gastrointestinal-tract-targeted oral mRNA delivery.

Aside from delivering the mRNA, the team also claims that the mechanical pill can also be used for delivering other macromolecules orally and can “achieve a maximum drug plasma concentration that is similar to the standard-of-care subcutaneous injection within 30 minutes after the oral administration”. Inspired from the leopard tortoise’s ability to passively reorient, the authors of the study claim that the robotic pill works by tunneling like a drill through the mucus protecting the GI tract. Upon testing the robotic pill to pigs in the study, the authors claimed that it could:

“…rapidly reach the stomach and enable self-orientation to the preferred upright position, allowing the injection of insulin-loaded tips into the mucosa within 1 minute, triggered by the dissolution of caramelized sucrose. The insulin loads were then released to the mucosa within 1 hour of the dissolution of the tips.”

According to David Rampulla, the director of the division of Discovery Science & Technology at National Institute of Biomedical Imaging and Bioengineering (NIBIB):

“Once the pill has been swallowed and reaches the stomach, it can orient itself properly so that “its injection mechanism is flush against the stomach wall. After a few minutes, a carbohydrate pellet at the top of the pill dissolves, activating a spring and enabling a needle to inject the biologic drug into the stomach tissue. Then, a second, newly exposed pellet dissolves, freeing the spring and retracting the needle back inside the pill, allowing for safe passage of the device through the gastrointestinal tract”.

Meanwhile, Dr. Peter McCullough continues to warn readers:

“In a nutshell, a pill would be swallowed and the devices would orient to the wall of the stomach or intestine (which would be difficult to control) and then the payload (mRNA) would be injected into the gastrointestinal epithelium and submucosa. The rich blood supply would immediately take the products into the bloodstream. From there, the portal circulation would take blood to the liver via the hepatic portal vein. No one knows what a direct shot of mRNA would do to the liver.”





Featured image: https://invivo.pharmaintelligence.informa.com/MT123193/Market-Intel-Robotic-Pills-And-The-Future-Of-Painless-Drug-Delivery